Characterisation of the secondary-neutron production in particle therapy treatments with the MONDO tracking detector

Particle Therapy (PT) is a non-invasive technique that exploits charged light ions for the irradiation of tumours that cannot be effectively treated with surgery or conventional radiotherapy. While the largest dose fraction is released to the tumour volume by the primary beam, a non-negligible amount of additional dose is due to the beam fragmentation that occurs along the path towards the target volume. In particular, the produced neutrons are particularly dangerous as they can release their energy far away from the treated area, increasing the risk of developing a radiogenic secondary malignant neoplasm after undergoing a treatment. A precise measurement of the neutron flux, energy spectrum and angular distributions is eagerly needed in order to improve the treatment planning system software, so as to predict the normal tissue toxicity in the target region and the risk of late complications in the whole body. The MONDO (MOnitor for Neutron Dose in hadrOntherapy) project is dedicated to the characterisation of the secondary ultra-fast neutrons ([20-400] MeV energy range) produced in PT. The neutron tracking system exploits the reconstruction of the recoil protons produced in two consecutive (n, p) elastic scattering interactions to measure simultaneously the neutron incoming direction and energy. The tracker active media is a matrix of thin squared scintillating fibers arranged in orthogonally oriented layers that are read out by a sensor (SBAM) based on SPAD (Single-Photon Avalanche Diode) detectors developed in collaboration with the Fondazione Bruno Kessler (FBK)

Massless versus Kaluza-Klein Gravitons at the LHC

We show that the LHC will be able to differentiate between a four-dimensional model with quantum gravity at ~1 TeV where the (massless) graviton becomes strongly coupled to standard model particles at 1 TeV and brane world type models with a large extra-dimensional volume and massive Kaluza-Klein gravitons. We estimate that the 14 TeV LHC could put a limit of the order of ~5 TeV on the four dimensional Planck mass in a model independent way.Comment: 9 page

Oblique Parameter Constraints on Large Extra Dimensions

We consider the Kaluza-Klein scenario in which gravity propagates in the $4+n$ dimensional bulk of spacetime and the Standard Model particles are confined to a 3-brane. We calculate the gauge boson self-energy corrections arising from the exchange of virtual gravitons and present our results in the $STU$-formalism. We find that the new physics contributions to $S$, $T$ and $U$ decouple in the limit that the string scale $M_S$ goes to infinity. The oblique parameters constrain the lower limit on $M_S$. Taking the quantum gravity cutoff to be $M_S$, $S$-parameter constraints impose $M_S>1.55$ TeV for $n=2$ at the 1$\sigma$ level. $T$-parameter constraints impose $M_S>1.25 (0.75)$ TeV for $n=3 (6)$.Comment: Version to appear in PR

A Large Mass Hierarchy from a Small Extra Dimension

We propose a new higher-dimensional mechanism for solving the Hierarchy Problem. The Weak scale is generated from a large scale of order the Planck scale through an exponential hierarchy. However, this exponential arises not from gauge interactions but from the background metric (which is a slice of AdS_5 spacetime). This mechanism relies on the existence of only a single additional dimension. We demonstrate a simple explicit example of this mechanism with two three-branes, one of which contains the Standard Model fields. The experimental consequences of this scenario are new and dramatic. There are fundamental spin-2 excitations with mass of weak scale order, which are coupled with weak scale as opposed to gravitational strength to the standard model particles. The phenomenology of these models is quite distinct from that of large extra dimension scenarios; none of the current constraints on theories with very large extra dimensions apply.Comment: 9 pages, LaTe

Large Extra Dimension Effects on the Spin Configuration of the Top Quark Pair at e^+ e^- Colliders

Large extra dimension effects on the spin configuration of the top quark pair at the $e^+ e^-\to t\bar{t}$ process are studied. It is shown that the TeV scale quantum gravity effects cause significant deviations from the Standard Model predictions for the spin configuration in the off-diagonal basis: they lead to substantial cross sections of the like-spin states of the top quark pair, which vanish in the SM; they weaken the pure dominance of the processes, the Up-Down (Down-Up) spin states for the left-handed (right-handed) beam. In addition it is shown that the angular cut $-0.5<\cos\theta<0$ is very effective to determine the sign of the quantum gravity corrections.Comment: A discussion on the angular distribution is added with a tabl

In-room test results at CNAO of an innovative PT treatments online monitor (Dose Profiler)

The use of C, He and O ions as projectiles in Particle Therapy (PT) treatments is getting more and more widespread as a consequence of their enhanced relative biological effectiveness and oxygen enhancement ratio, when compared to the protons one. The advantages related to the incoming radiation improved efficacy are requiring an accurate online monitor of the dose release spatial distribution. Such monitor is necessary to prevent unwanted damage to the tissues surrounding the tumour that can arise, for example, due to morphological changes occurred in the patient during the treatment with respect to the initial CT scan. PT treatments with ions can be monitored by detecting the secondary radiation produced by the primary beam interactions with the patient body along the path towards the target volume. Charged fragments produced in the nuclear process of projectile fragmentation can be emitted at large angles with respect to the incoming beam direction and can be detected with high efficiency in a nearly background-free environment. The Dose Profiler (DP) detector, developed within the INSIDE project, is a scintillating fibre tracker that allows an online reconstruction and backtracking of such secondary charged fragments. The construction and preliminary in-room tests performed on the DP, carried out using the 12C ions beam of the CNAO treatment centre using an anthropomorphic phantom as a target, will be reviewed in this contribution. The impact of the secondary fragments interactions with the patient body will be discussed in view of a clinical application. Furthermore, the results implications for a pre-clinical trial on CNAO patients, foreseen in 2019, will be discussed

Brane fluctuations and suppression of Kaluza-Klein mode couplings

In higher dimensional models where the gauge and gravity fields live in the bulk and the matter fields only in a brane, we point out the importance of the brane (transverse) coordinate modes, which are the Nambu-Goldstone bosons appearing as a result of spontaneous breaking of the translation symmetry. The brane recoil effect suppresses the couplings of higher Kaluza-Klein modes to the matter, and gives a natural resolution to the divergence problem caused by the exchange of infinitely many Kaluza-Klein modes.Comment: 11 pages, 1 eps figure, references adde

Cosmological Constraints on Theories with Large Extra Dimensions

In theories with large extra dimensions, constraints from cosmology lead to non-trivial lower bounds on the fundamental scale M_F, corresponding to upper bounds on the radii of the compact extra dimensions. These constraints are especially relevant to the case of two extra dimensions, since only if M_F is 10 TeV or less do deviations from the standard gravitational force law become evident at distances accessible to planned sub-mm gravity experiments. By examining the graviton decay contribution to the cosmic diffuse gamma radiation, we derive, for the case of two extra dimensions, a conservative bound M_F > 110 TeV, corresponding to r_2 < 5.1 times 10^-5 mm, well beyond the reach of these experiments. We also consider the constraint coming from graviton overclosure of the universe and derive an independent bound M_F > 6.5 h^(-1/2) TeV, or r_2 < .015 h mm.Comment: 10 pages, references adde